Great article, I thought you explained the 'function' well.
When it comes to things like Semaglutidez, LLMs, etc, I like to apply an adage I heard on an IT podcast: "Change is great; you go first."
Semaglutides sound great for anyone with any type of addiction; food, cigarettes, who knows, maybe even things like gambling, or social media. Personally, I'll wait to see some long-term use and studies before I ever consider using it.
Yes, I have been prescribed several different GLP-1s. Mounjaro worked great, but wasn't covered by insurance at $1k+. That will eventually change, but the delay in getting these drugs will take years off the lives of those who benefit from them. In the meantime, I'm taking a cheaper drug that is less effective but works over time. It feels like I'm racing against the clock.
A different GLP inhibitor? No need to share specifics if you don't want to, but whatever personal experiences you're comfortable with would be great to hear.
I am a diabetic and used Victoza for a while. Great if you like burping rotten eggs from undigested food hanging around in your belly. I finally made dietary changes and got off of it. Now I am 6'3" and 170 pounds down from 245. Perturbing complex systems is not advisable.
Wow, that's a crazy weight loss! If it's sustainable, I am really happy for you. I can only imagine that's a healthier weight, although you're also skinny like me. I'm probably 6'0" and around 155, depending on the day.
Weight loss was easy once I developed a system of keeping track of what I was putting in my mouth. Mostly low carb-high protein. I also only eat what will fit a bowl I use. So, portions and low carbs will do it. Writing things down also helps. Do not assume you can guess the carbs. I saw the doctor Friday and he said I'm starting to have too much weight loss. I just wanted to avoid going to insulin, and it worked. I need a new algorithm for eating. :-)
Context is everything. See: epigenetics. Even identical twins are different day one. Stem cells are fascinating and haven't received the widespread attention they deserve. Embryogenesis is a miracle.
Great explanation on how these drugs work. In one of my recent interviews with dietitian and diabetes educator Megrette Fletcher, she touched on how these are game-changing medications for managing blood sugar, but in the future she predicted, we'd see them used for other illnesses and conditions but at much smaller doses.
Thanks, Kristi! I am so interested now that I realize (and the data supports) that there's a huge brain-body connection here, and of course I want to better understand how that all works. Our minds, it seems, are far from contained within our skulls.
On a tangentially related note, the company behind Ozempic is the Danish firm called Novo Nordisk, and I used to work not so far from their location in Ballerup during my Jabra (GN Store Nord) days. I also have many ex-colleagues who went on to work for Novo, and by all accounts, it's a great company to work for.
That is good to hear! I'm not sure about the long term implications of all the drugs they're making, especially the explosion in popularity overnight with GLP-1 inhibitors, but it is great to hear that the people who work there are treated well. They have 69,000 employees worldwide, and treating people well has a positive multiplier effect, too.
Great article, I thought you explained the 'function' well.
When it comes to things like Semaglutidez, LLMs, etc, I like to apply an adage I heard on an IT podcast: "Change is great; you go first."
Semaglutides sound great for anyone with any type of addiction; food, cigarettes, who knows, maybe even things like gambling, or social media. Personally, I'll wait to see some long-term use and studies before I ever consider using it.
"Change is great; you go first" is my spirit slogan. I love it.
That certainly goes for any kind of brain augmentation, right?
Yes, I have been prescribed several different GLP-1s. Mounjaro worked great, but wasn't covered by insurance at $1k+. That will eventually change, but the delay in getting these drugs will take years off the lives of those who benefit from them. In the meantime, I'm taking a cheaper drug that is less effective but works over time. It feels like I'm racing against the clock.
A different GLP inhibitor? No need to share specifics if you don't want to, but whatever personal experiences you're comfortable with would be great to hear.
I am constantly shocked at the difference in price between Britain and America. Here it costs somewhere between £100 – £150 a month.
Yeah, this is enormous and ridiculous. I don't think it'll last for much longer, gut in the meantime, there are lots of folks caught in the cracks.
Metformin. It’s not a GLP inhibitor but has similar effects and costs about $1 per month.
I also misspoke: it's an agonist, not an inhibitor. Doh!
I am a diabetic and used Victoza for a while. Great if you like burping rotten eggs from undigested food hanging around in your belly. I finally made dietary changes and got off of it. Now I am 6'3" and 170 pounds down from 245. Perturbing complex systems is not advisable.
Wow, that's a crazy weight loss! If it's sustainable, I am really happy for you. I can only imagine that's a healthier weight, although you're also skinny like me. I'm probably 6'0" and around 155, depending on the day.
I'm going for welterweight! :-)
Weight loss was easy once I developed a system of keeping track of what I was putting in my mouth. Mostly low carb-high protein. I also only eat what will fit a bowl I use. So, portions and low carbs will do it. Writing things down also helps. Do not assume you can guess the carbs. I saw the doctor Friday and he said I'm starting to have too much weight loss. I just wanted to avoid going to insulin, and it worked. I need a new algorithm for eating. :-)
Just increase your bowl size!
Context is everything. See: epigenetics. Even identical twins are different day one. Stem cells are fascinating and haven't received the widespread attention they deserve. Embryogenesis is a miracle.
Great explanation on how these drugs work. In one of my recent interviews with dietitian and diabetes educator Megrette Fletcher, she touched on how these are game-changing medications for managing blood sugar, but in the future she predicted, we'd see them used for other illnesses and conditions but at much smaller doses.
Thanks, Kristi! I am so interested now that I realize (and the data supports) that there's a huge brain-body connection here, and of course I want to better understand how that all works. Our minds, it seems, are far from contained within our skulls.
On a tangentially related note, the company behind Ozempic is the Danish firm called Novo Nordisk, and I used to work not so far from their location in Ballerup during my Jabra (GN Store Nord) days. I also have many ex-colleagues who went on to work for Novo, and by all accounts, it's a great company to work for.
That is good to hear! I'm not sure about the long term implications of all the drugs they're making, especially the explosion in popularity overnight with GLP-1 inhibitors, but it is great to hear that the people who work there are treated well. They have 69,000 employees worldwide, and treating people well has a positive multiplier effect, too.