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j.e. moyer, LPC's avatar

Yes, I have been prescribed several different GLP-1s. Mounjaro worked great, but wasn't covered by insurance at $1k+. That will eventually change, but the delay in getting these drugs will take years off the lives of those who benefit from them. In the meantime, I'm taking a cheaper drug that is less effective but works over time. It feels like I'm racing against the clock.

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Andrew Smith's avatar

A different GLP inhibitor? No need to share specifics if you don't want to, but whatever personal experiences you're comfortable with would be great to hear.

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Lizzie Wingfield's avatar

I am constantly shocked at the difference in price between Britain and America. Here it costs somewhere between £100 – £150 a month.

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Andrew Smith's avatar

Yeah, this is enormous and ridiculous. I don't think it'll last for much longer, gut in the meantime, there are lots of folks caught in the cracks.

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j.e. moyer, LPC's avatar

Metformin. It’s not a GLP inhibitor but has similar effects and costs about $1 per month.

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Andrew Smith's avatar

I also misspoke: it's an agonist, not an inhibitor. Doh!

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hexheadtn's avatar

I am a diabetic and used Victoza for a while. Great if you like burping rotten eggs from undigested food hanging around in your belly. I finally made dietary changes and got off of it. Now I am 6'3" and 170 pounds down from 245. Perturbing complex systems is not advisable.

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Andrew Smith's avatar

Wow, that's a crazy weight loss! If it's sustainable, I am really happy for you. I can only imagine that's a healthier weight, although you're also skinny like me. I'm probably 6'0" and around 155, depending on the day.

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hexheadtn's avatar

I'm going for welterweight! :-)

Weight loss was easy once I developed a system of keeping track of what I was putting in my mouth. Mostly low carb-high protein. I also only eat what will fit a bowl I use. So, portions and low carbs will do it. Writing things down also helps. Do not assume you can guess the carbs. I saw the doctor Friday and he said I'm starting to have too much weight loss. I just wanted to avoid going to insulin, and it worked. I need a new algorithm for eating. :-)

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Andrew Smith's avatar

Just increase your bowl size!

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hexheadtn's avatar

Context is everything. See: epigenetics. Even identical twins are different day one. Stem cells are fascinating and haven't received the widespread attention they deserve. Embryogenesis is a miracle.

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Kristi Koeter's avatar

Great explanation on how these drugs work. In one of my recent interviews with dietitian and diabetes educator Megrette Fletcher, she touched on how these are game-changing medications for managing blood sugar, but in the future she predicted, we'd see them used for other illnesses and conditions but at much smaller doses.

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Andrew Smith's avatar

Thanks, Kristi! I am so interested now that I realize (and the data supports) that there's a huge brain-body connection here, and of course I want to better understand how that all works. Our minds, it seems, are far from contained within our skulls.

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Daniel Nest's avatar

On a tangentially related note, the company behind Ozempic is the Danish firm called Novo Nordisk, and I used to work not so far from their location in Ballerup during my Jabra (GN Store Nord) days. I also have many ex-colleagues who went on to work for Novo, and by all accounts, it's a great company to work for.

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Andrew Smith's avatar

That is good to hear! I'm not sure about the long term implications of all the drugs they're making, especially the explosion in popularity overnight with GLP-1 inhibitors, but it is great to hear that the people who work there are treated well. They have 69,000 employees worldwide, and treating people well has a positive multiplier effect, too.

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Jan 20
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Andrew Smith's avatar

"Change is great; you go first" is my spirit slogan. I love it.

That certainly goes for any kind of brain augmentation, right?

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