12 Comments

Great article, I thought you explained the 'function' well.

When it comes to things like Semaglutidez, LLMs, etc, I like to apply an adage I heard on an IT podcast: "Change is great; you go first."

Semaglutides sound great for anyone with any type of addiction; food, cigarettes, who knows, maybe even things like gambling, or social media. Personally, I'll wait to see some long-term use and studies before I ever consider using it.

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"Change is great; you go first" is my spirit slogan. I love it.

That certainly goes for any kind of brain augmentation, right?

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Yes, I have been prescribed several different GLP-1s. Mounjaro worked great, but wasn't covered by insurance at $1k+. That will eventually change, but the delay in getting these drugs will take years off the lives of those who benefit from them. In the meantime, I'm taking a cheaper drug that is less effective but works over time. It feels like I'm racing against the clock.

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A different GLP inhibitor? No need to share specifics if you don't want to, but whatever personal experiences you're comfortable with would be great to hear.

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I am constantly shocked at the difference in price between Britain and America. Here it costs somewhere between £100 – £150 a month.

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Yeah, this is enormous and ridiculous. I don't think it'll last for much longer, gut in the meantime, there are lots of folks caught in the cracks.

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Metformin. It’s not a GLP inhibitor but has similar effects and costs about $1 per month.

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I also misspoke: it's an agonist, not an inhibitor. Doh!

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Great explanation on how these drugs work. In one of my recent interviews with dietitian and diabetes educator Megrette Fletcher, she touched on how these are game-changing medications for managing blood sugar, but in the future she predicted, we'd see them used for other illnesses and conditions but at much smaller doses.

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Thanks, Kristi! I am so interested now that I realize (and the data supports) that there's a huge brain-body connection here, and of course I want to better understand how that all works. Our minds, it seems, are far from contained within our skulls.

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On a tangentially related note, the company behind Ozempic is the Danish firm called Novo Nordisk, and I used to work not so far from their location in Ballerup during my Jabra (GN Store Nord) days. I also have many ex-colleagues who went on to work for Novo, and by all accounts, it's a great company to work for.

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That is good to hear! I'm not sure about the long term implications of all the drugs they're making, especially the explosion in popularity overnight with GLP-1 inhibitors, but it is great to hear that the people who work there are treated well. They have 69,000 employees worldwide, and treating people well has a positive multiplier effect, too.

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